http://download.springer.com/static/pdf/136/art%253A10.1007%252Fs40264-016-0456-3.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs40264-016-0456-3&token2=exp=1474119145~acl=%2Fstatic%2Fpdf%2F136%2Fart%25253A10.1007%25252Fs40264-016-0456-3.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs40264-016-0456-3*~hmac=3f5044637138c03474e92015925778fa27ceb2e42659809389ee41c435e35bc6